Thyroid-stimulating hormone (TSH), its history and diseases caused by high or low level of TSH

Thyroid-stimulating hormone: 

The origin of the Thyroid-stimulating hormone is Pituitary gland. Thyroid-stimulating hormone stimulates the Thyroid gland to produce Thyroxine. 

Thyroid gland presents in the neck region. Thyroid-stimulating hormone maintains the level of Thyroxine in blood which controls many functions of the body. 


What is the history of TSH? 

  •   Thyroid-stimulating hormone produced in 1926,  from the University of Maryland Medical School
  •    Eduard Uhlenhuth discovered the Thyroid-stimulating hormone.  


What is the normal values of TSH?    

  • The normal values of TSH hormone in human body is 0.5 to 5.0 mI U/L.


What happens if TSH is in high level? 

  • High level of TSH causes the disease of hyperthyroidism.   


Symptoms of hyperthyroidism: 

  •   Nervousness
  •   Anxiety
  •   Tremor
  •   Weight loss
  •   Shortness of breath
  •   Heart failure
  •   Irritability
  •   Mood swings
  •   Palpitations
  •   Arrhythmia  
  •   Cold intolerance
  •   Constipation


What happens if TSH is in low level? 

  • Low level of TSH causes the diseases of Goiter, Thyroiditis, Toxic nodules on your thyroid. 

Symptoms of low level of TSH:

  •   Weight loss 
  •   Bulging eyes
  •   Sleeping sickness
  •   Fatigue
  •   Light sensitivity
  •   Excess sweating
  •   Brittle hairs
  •   Diarrhea
  •   High blood pressure
  •   Muscle weakness
  •   Rapid heartbeat 
  •   Mood changes
  •   Dizziness 


Factors that effects the levels of TSH: 

  •   Medications 
  •   Supplements
  •   Pollutants
  •   Smoking
  •   Autoantibodies
  •   Heterophilic antibodies
  •   Diet and iodine level
  •   Ethnicity
  •   Age
  •   Gender
  •   Time of daytime of year
  •   Concomitant diseases

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